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In general, they exert their effect through binding to specific high-affinity receptors on the respective target cell receptors [25]

In a long-term randomized, double-blind, placebo-controlled study among sufferers of cerebrovascular accidents at high risk of depression, daily supplementation with 2 mg of folic acid, 25 mg of vitamin B6, and 500 g vitamin B 12 significantly lowered the risk of major depressive episodes during a seven-year follow-up period compared to placebo (111)

They are effective and cause minimal side effects

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Cellular uptake and energy support Once the B12 reaches your cells, it enters the mitochondriathe powerhouse of your cells